Journal article
Long-term impact of pneumococcal polysaccharide vaccination on nasopharyngeal carriage in children previously vaccinated with various pneumococcal conjugate vaccine regimes
LK Boelsen, EM Dunne, KE Lamb, K Bright, YB Cheung, L Tikoduadua, FM Russell, EK Mulholland, PV Licciardi, C Satzke
Vaccine | ELSEVIER SCI LTD | Published : 2015
Abstract
Previously, the Fiji Pneumococcal Project (FiPP) evaluated reduced dose immunization schedules that incorporated pneumococcal protein conjugate and/or polysaccharide vaccine (PCV7 and 23vPPV, respectively). Immune hyporesponsiveness was observed in children vaccinated with 23vPPV at 12 months of age compared with children who did not receive 23vPPV. Here we assess the long-term impact of 23vPPV vaccination on nasopharyngeal carriage rates and densities of Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus and Moraxella catarrhalis. Nasopharyngeal swabs (n= 194) were obtained from healthy children who participated in FiPP (now aged 5-7 years). S. pneumoniae were isolated ..
View full abstractGrants
Awarded by Victorian Centre for Biostatistics
Funding Acknowledgements
We thank all the participants, families and staff involved in FiPP and this study. This work was funded by National Institutes of Health (NIH), USA (NIH Grant 1R01A1085198-01A1) and was supported by the Victorian Government's Operational Infrastructure Support Program. Laura Boelsen is supported by the Fay Manes Scholarship (The University of Melbourne). Paul Licciardi and Fiona Russell are recipients of the Australian National Health and Medical Research Council (NHMRC) Early Career Fellowship (APP1013820 and APP1035341), and Catherine Satzke is a recipient of the Australian NHMRC Career Development Fellowship (APP1087957). Karen Lamb was supported under a National Health and Medical Research Council Centre of Research Excellence grant (ID31035261) to the Victorian Centre for Biostatistics (ViCBiostat).