Journal article
Bias and precision of measures of survival gain from right-censored data
Karen E Lamb, Elizabeth J Williamson, Michael Coory, John B Carlin
PHARMACEUTICAL STATISTICS | WILEY-BLACKWELL | Published : 2015
DOI: 10.1002/pst.1700
Abstract
In cost-effectiveness analyses of drugs or health technologies, estimates of life years saved or quality-adjusted life years saved are required. Randomised controlled trials can provide an estimate of the average treatment effect; for survival data, the treatment effect is the difference in mean survival. However, typically not all patients will have reached the endpoint of interest at the close-out of a trial, making it difficult to estimate the difference in mean survival. In this situation, it is common to report the more readily estimable difference in median survival. Alternative approaches to estimating the mean have also been proposed. We conducted a simulation study to investigate th..
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Awarded by National Health and Medical Research Council Centre of Research Excellence
Funding Acknowledgements
K. E. L. was supported under a National Health and Medical Research Council Centre of Research Excellence grant, ID#1035261, to the Victorian Centre for Biostatistics (ViCBiostat). Research on this paper at the Murdoch Childrens Research Institute was supported by the Victorian Government's Operational Infrastructure Support Program.