SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia
M Udawela, TT Money, J Neo, MS Seo, E Scarr, B Dean, IP Everall
Translational Psychiatry | NATURE PUBLISHING GROUP | Published : 2015
Selenium binding protein 1 (SELENBP1) messenger RNA (mRNA) has previously been shown to be upregulated in the brain and blood from subjects with schizophrenia. We aimed to validate these findings in a new cohort using real-time PCR in Brodmann's Area (BA) 9, and to determine the disease specificity of increased SELENBP1 expression by measuring SELENBP1 mRNA in subjects with major depressive disorder and bipolar disorder. We then extended the study to include other cortical regions such as BA8 and BA44. SELENBP1 mRNA was higher in BA9 (P = 0.001), BA8 (P = 0.003) and BA44 (P = 0.0007) from subjects with schizophrenia. Conversely, in affective disorders, there was no significant difference in ..View full abstract
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Awarded by NHMRC
Awarded by Australian Research Council
We gratefully acknowledge the assistance of Geoffrey Pavey for the preparation of post-mortem tissue, Chad Bousman for the ancestry marker and genotyping data collection, and Aradhana Upadhyay and Gayathri Perera for their assistance with sample preparation. This project was supported by the NHMRC (project grant 566967, Centre for Research Excellence Grant 1001216 (TTM), Senior Research Fellowship no. APP1002240 (BD)), the Australian Research Council (Future Fellowship FT100100689 to ES), as well as Operational Infrastructure Support from the Victorian State Government, the Rebecca L. Cooper Medical Research Foundation and the Cooperative Research Centre for Mental Health.