Journal article

Applications of Induced Pluripotent Stem Cells in Studying the Neurodegenerative Diseases

Wenbin Wan, Lan Cao, Bill Kalionis, Shijin Xia, Xiantao Tai

STEM CELLS INTERNATIONAL | HINDAWI LTD | Published : 2015

Abstract

Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons. Incurable neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) show dramatic rising trends particularly in the advanced age groups. However, the underlying mechanisms are not yet fully elucidated, and to date there are no biomarkers for early detection or effective treatments for the underlying causes of these diseases. Furthermore, due to species variation and differences between animal models (e.g., mouse transgenic and knockout models) of neurodegenerative diseases, substantial debate focuses on whether animal and cell culture disease models can correct..

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