An assessment of pancreatic endocrine function and insulin sensitivity in patients with transient neonatal diabetes in remission

Abstract

Aims: To examine derived indices of β cell function, peripheral insulin sensitivity, and the pancreatic response to intravenous glucose loading in children with a previous history of transient neonatal diabetes currently in remission, repeated after a period of two or more years. Methods: The standard intravenous glucose tolerance test (IVGTT) was used to measure the first phase insulin response (FPIR) cumulatively at one and three minutes. In addition, fasting insulin and glucose values were used to estimate insulinogenic indices (β cell function) and QUICKI (insulin sensitivity). Patients: Six patients with known previous transient neonatal diabetes currently in remission with no exogenous..