Journal article

Breast cancer risk for Korean women with germline mutations in BRCA1 and BRCA2

Boyoung Park, James G Dowty, Choonghyun Ahn, Aung K Win, Sung-Won Kim, Min Hyuk Lee, Jong Won Lee, Eunyoung Kang, John L Hopper, Sue K Park

BREAST CANCER RESEARCH AND TREATMENT | SPRINGER | Published : 2015

Abstract

The average age-specific cumulative risk (penetrance) of breast cancer has been studied for BRCA1 and BRCA2 mutation carriers living in Western countries, but not for those living in East Asian countries where the population breast cancer incidence is lower. From 2007 to 2011, the Korean Hereditary Breast Cancer study identified 151 BRCA1 and 225 BRCA2 mutation-carrying families from family cancer clinics. We estimated the hazard ratio (HR) for female carriers relative to the population, and hence the penetrance, using a modified segregation analysis of cancer family histories conditioned on ascertainment. The breast cancer HR estimates [95 % confidence interval (CI)] for BRCA1 and BRCA2 mut..

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