Journal article

Impaired learning from errors in cannabis users: Dorsal anterior cingulate cortex and hippocampus hypoactivity

Susan E Carey, Liam Nestor, Jennifer Jones, Hugh Garavan, Robert Hester

DRUG AND ALCOHOL DEPENDENCE | ELSEVIER IRELAND LTD | Published : 2015

Abstract

BACKGROUND: The chronic use of cannabis has been associated with error processing dysfunction, in particular, hypoactivity in the dorsal anterior cingulate cortex (dACC) during the processing of cognitive errors. Given the role of such activity in influencing post-error adaptive behaviour, we hypothesised that chronic cannabis users would have significantly poorer learning from errors. METHODS: Fifteen chronic cannabis users (four females, mean age=22.40 years, SD=4.29) and 15 control participants (two females, mean age=23.27 years, SD=3.67) were administered a paired associate learning task that enabled participants to learn from their errors, during fMRI data collection. RESULTS: Compared ..

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Grants

Awarded by USPHS from the National Institute on Drug Abuse


Awarded by Australian Research Council


Awarded by NATIONAL INSTITUTE ON DRUG ABUSE


Funding Acknowledgements

This study was supported by USPHS grant from the National Institute on Drug Abuse: DA01865-01, Australian Research Council Future Fellowship (RH) FT110100088. Neither funding agency had any further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.