Journal article
Genomic prediction of celiac disease targeting HLA-positive individuals
G Abraham, A Rohmer, JA Tye-Din, M Inouye
Genome Medicine | Published : 2015
Abstract
Background: Genomic prediction aims to leverage genome-wide genetic data towards better disease diagnostics and risk scores. We have previously published a genomic risk score (GRS) for celiac disease (CD), a common and highly heritable autoimmune disease, which differentiates between CD cases and population-based controls at a clinically-relevant predictive level, improving upon other gene-based approaches. HLA risk haplotypes, particularly HLA-DQ2.5, are necessary but not sufficient for CD, with at least one HLA risk haplotype present in up to half of most Caucasian populations. Here, we assess a genomic prediction strategy that specifically targets this common genetic susceptibility subtyp..
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Awarded by National Institute of Diabetes and Digestive and Kidney Diseases
Funding Acknowledgements
[ "The North American Celiac Disease Consortium study was conducted by the North American Celiac Disease Consortium Investigators and supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The data from the North American Celiac Disease Consortium reported here were supplied by the NIDDK Central Repositories. This manuscript was not prepared in collaboration with Investigators of the North American Celiac Disease Consortium study and does not necessarily reflect the opinions or views of the North American Celiac Disease Consortium study, the NIDDK Central Repositories, or the NIDDK.", "The authors acknowledge support and funding from NHMRC grant no. 1062227. GA was supported by an NHMRC Early Career Fellowship (no. 1090462). MI was supported by a Career Development Fellowship co-funded by the NHMRC and Heart Foundation (no. 1061435)." ]