Phase Transfer Catalysis Extends The Scope of The Algar-Flynn-Oyamada Synthesis of 3-Hydroxyflavones
Nhu Duong, Bill C Hawkins, Christopher J Burns
Australian Journal of Chemistry | CSIRO PUBLISHING | Published : 2015
The Algar-Flynn-Oyamada reaction is the classical method to synthesize 3-hydroxyflavones from chalcones. Despite its relative simplicity, the reaction has several drawbacks including variable and often low product yields. We have found that phase transfer catalysis improves the yields and expands the scope of the Algar-Flynn-Oyamada reaction of a series of 4-benzyloxy-2-hydroxy chalcones.
Awarded by Independent Research Institutes Infrastructure Support Scheme Grant from the Australian National Health and Medical Research Council
This work was supported by scholarships, fellowships, and grants from the following: Victorian State Government Operational Infrastructure Support (OIS) Grant, Australian Cancer Research Foundation, Cancer Therapeutics CRC (DN), Dyson Bequest funding (CJB), and an Independent Research Institutes Infrastructure Support Scheme Grant (361646) from the Australian National Health and Medical Research Council. Prof. David Huang and Assoc. Prof. Spencer Williams are thanked for useful discussions. Ms Dana Buczek is acknowledged for analytical support.