Journal article

CLONING AND CHARACTERIZATION OF THE PROMOTER FOR THE RAT INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-3 GENE

AL ALBISTON, R SAFFERY, AC HERINGTON

ENDOCRINOLOGY | ENDOCRINE SOC | Published : 1995

Abstract

Insulin-like growth factor-binding protein-3 (IGFBP-3), the major IGFBP in the adult circulation, is produced by a wide range of cell and tissue types. IGFBP-3 appears to be regulated by transcriptional and/or posttranslational mechanisms in a species-, cell-, and development-specific manner. In vitro and in vivo studies suggest that a number of factors (e.g. cAMP, GH, insulin-like growth factor-I, epidermal growth factor, TSH, and FSH) can act as transcriptional regulators of IGFBP-3 in particular cell types. To address the mechanistic basis for these observations, we isolated the rat IGFBP-3 gene and began characterization and analysis of the hormonal regulation of its promoter. The rat IG..

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