Journal article

Delayed healing of lower limb fractures with bisphosphonate therapy

B Yue, A Ng, H Tang, S Joseph, M Richardson

Annals of The Royal College of Surgeons of England | ROYAL COLL SURGEONS ENGLAND | Published : 2015

Abstract

INTRODUCTION: Bisphosphonate therapy (BT) is used commonly in the management of osteoporosis. A systematic review was conducted investigating delayed union of lower limb, long bone fractures in patients on BT. We specifically assessed whether BT increases the risk of delayed union or non-union in lower limb, long bone fractures. METHODS: A literature search was conducted in the PubMed and Embase™ on 4 November 2014. Articles that investigated lower limb fractures, history of BT and fracture union were included in the review. RESULTS: A total of 9,809 papers were retrieved and 14 were deemed suitable for this review. The mean time to union in patients on BT was 8.5 months. A longer time to un..

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University of Melbourne Researchers