Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells

Benjamin J Wolf; Raju VV Tatituri; Catarina F Almeida; Jerome Le Nours; Veemal Bhowruth; Darryl Johnson; Adam P Uldrich; Fong-Fu Hsu; Manfred Brigl; Gurdyal S Besra; Jamie Rossjohn; Dale I Godfrey; Michael B Brenner

Journal article

Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells

Benjamin J Wolf, Raju VV Tatituri, Catarina F Almeida, Jerome Le Nours, Veemal Bhowruth, Darryl Johnson, Adam P Uldrich, Fong-Fu Hsu, Manfred Brigl, Gurdyal S Besra, Jamie Rossjohn, Dale I Godfrey, Michael B Brenner

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2015

DOI: 10.4049/jimmunol.1501019

University of Melbourne Researchers

Dale Godfrey Author Microbiology and Immunology

Catarina Dos Santos Sa E Almeida Author Microbiology and Immunology

Adam Uldrich Author Microbiology and Immunology

Darryl Johnson Author Microbiology and Immunology

Related Projects (6)

Recognition of lipid antigens by the immune system.

T cells are a critical component of the immune system, protecting against a range of pathogens by detecting and responding to foreign molecu..

RECOGNITION OF LIPID ANTIGENS BY THE IMMUNE SYSTEM.

T cells are a critical component of the immune system, protecting against a range of pathogens by detecting and responding to foreign molecu..

Self-reactivity by NKT cells

NKT cells are a type of lymphocyte with the ability to prevent a broad range of diseases including cancer, autoimmunity, infection and graft..

RESEARCH FELLOWSHIP

Professor Godfrey is an immunologist with a long standing history as a pioneer in the study of a specialised type of white blood cell, known..

IMMUNE REGULATION EFFECTOR FUNCTION AND THERAPY

We seek to understand how white blood cells detect and destroy disease, and how molecules of the immune system punch holes in diseased cells..

IMMUNE REGULATION EFFECTOR FUNCTION AND THERAPY

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Grants

Awarded by National Institutes of Health

Awarded by National Health and Medical Research Council of Australia

Awarded by Australian Research Council

Awarded by Medical Research Council

Awarded by Washington University Mass Spectrometry Resource

Awarded by Fundacao para a Ciencia e Tecnologia International PhD Programme from Ministerio da Educacao e Ciencia, Portugal

Awarded by National Health and Medical Research Council of Australia Senior Principal Research Fellowship

Awarded by Australian Research Council Future Fellowship

Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

Funding Acknowledgements

This work was supported by National Institutes of Health Grants 5R01AI063428-09 and 5T32AR007530-30 (to the Brenner Laboratory), National Health and Medical Research Council of Australia Grants 1021972 and 1013667 (to the Godfrey Laboratory), and Australian Research Council Grant CE140100011. G.S.B. acknowledges support in the form of a Personal Research Chair from Mr. James Bardrick and the Medical Research Council (MR/K012118/1). F.-F.H. was supported by Washington University Mass Spectrometry Resource Grants P41-GM103422, P60-DK-20579, and P30-DK56341. M.B.B. was supported by National Institutes of Health Grants 5K08AI077795 and 1R21AI103616. C.F.A. was supported by Fundacao para a Ciencia e Tecnologia International PhD Programme SFRH/BD/74906/2010 from Ministerio da Educacao e Ciencia, Portugal. D.I.G. was supported by National Health and Medical Research Council of Australia Senior Principal Research Fellowship 1020770. J.R. was supported by a National Health and Medical Research Council of Australia Fellowship, the National Health and Medical Research Council of Australia, and the Australian Research Council. A.P.U. was supported by Australian Research Council Future Fellowship FT140100278.