Journal article
Analytical bias in the measurement of serum 25-hydroxyVitamin D concentrations impairs assessment of Vitamin D status in clinical and research settings
LJ Black, D Anderson, MW Clarke, AL Ponsonby, RM Lucas
Plos One | Published : 2015
Abstract
Measured serum 25-hydroxyvitamin D concentrations vary depending on the type of assay used and the specific laboratory undertaking the analysis, impairing the accurate assessment of vitamin D status. We investigated differences in serum 25-hydroxyvitamin D concentrations measured at three laboratories (laboratories A and B using an assay based on liquid chroma-tography-tandem mass spectrometry and laboratory C using a DiaSorin Liaison assay), against a laboratory using an assay based on liquid chromatography-tandem mass spectrome-try that is certified to the standard reference method developed by the National Institute of Standards and Technology and Ghent University (referred to as the 'cer..
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Awarded by National Multiple Sclerosis Society of the USA
Funding Acknowledgements
This study was supported by grants from the National Multiple Sclerosis Society of the USA (RG3364A1/2), the National Health and Medical Research Council (NHMRC) of Australia, and Multiple Sclerosis Research Australia. LJB and DA were supported by the Telethon Kids Institute; MWC was supported by Bioplatforms Australia (NCRIS) and the Western Australian Government Innovation Co-investment Program (ICP); A-LP and RML were supported by NHMRC Fellowships.