A Toxoplasma gondii Gluconeogenic Enzyme Contributes to Robust Central Carbon Metabolism and Is Essential for Replication and Virulence

Martin Blume; Richard Nitzsche; Ulrich Sternberg; Motti Gerlic; Seth L Masters; Nishith Gupta; Malcolm J McConville

Journal article

A Toxoplasma gondii Gluconeogenic Enzyme Contributes to Robust Central Carbon Metabolism and Is Essential for Replication and Virulence

Martin Blume, Richard Nitzsche, Ulrich Sternberg, Motti Gerlic, Seth L Masters, Nishith Gupta, Malcolm J McConville

Cell Host & Microbe | CELL PRESS | Published : 2015

DOI: 10.1016/j.chom.2015.07.008

University of Melbourne Researchers

Malcolm McConville Author Biochemistry and Molecular Biology

Seth Masters Author Medical Biology (W.E.H.I.)

Grants

Awarded by Australian NHMRC

Awarded by German Research Foundation (DFG)

Awarded by DFG

Funding Acknowledgements

We thank Chris Tonkin, Giel van Dooren, Boris Striepen, Dominque Soldati-Favre, Paul Gleeson, and Geoff McFadden for generously sharing antibodies, plasmids, and parasite lines. We also thank Julie Ralton for experimental advice and Stuart Ralph for critical reading of the manuscript. This work was supported by Australian NHMRC project grant APP1057815. M.J.M. is a NHMRC Principal Research fellow. M.B. was supported by a DFG research fellowship and a PhD fellowship from the Helmholtz Foundation of Germany (Humboldt University of Berlin). N.G. was supported by German Research Foundation (DFG) grants GRK1121/A7 and a DFG grant GU1100/3-1.