Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study

GP Amminger; MR Schäfer; M Schlögelhofer; CM Klier; PD McGorry

Journal article

Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study

GP Amminger, MR Schäfer, M Schlögelhofer, CM Klier, PD McGorry

Nature Communications | NATURE PORTFOLIO | Published : 2015

DOI: 10.1038/ncomms8934

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Abstract

Long-chain omega-3 polyunsaturated fatty acids (PUFAs) are essential for neural development and function. As key components of brain tissue, omega-3 PUFAs play critical roles in brain development and function, and a lack of these fatty acids has been implicated in a number of mental health conditions over the lifespan, including schizophrenia. We have previously shown that a 12-week intervention with omega-3 PUFAs reduced the risk of progression to psychotic disorder in young people with subthreshold psychotic states for a 12-month period compared with placebo. We have now completed a longer-term follow-up of this randomized, double-blind, placebo-controlled trial, at a median of 6.7 years. ..

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University of Melbourne Researchers

Paul Amminger Author

Patrick McGorry Author

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Grants

Awarded by Stanley Medical Research Institute

Funding Acknowledgements

This work was supported by grant 03T-315 from the Stanley Medical Research Institute. G.P.A. was supported by National Health and Medical Research Council Australia (NHMRC) Senior Research Fellowship (ID: 1080963); P.D.M. was supported by NHMRC Senior Principal Research Fellowship (ID: 1060996). Nandita Vijayakumar contributed to the data analysis; Konstantinos Papageorgiou assisted with data collection and data entry; and Dr Sherilyn Goldstone edited the final manuscript. We thank all of the participants and their families.