Effects of omega-3 PUFA on the vitamin E and glutathione antioxidant defense system in individuals at ultra-high risk of psychosis

Stefan Smesny; Berko Milleit; Miriam R Schaefer; Uta-Christina Hipler; Christine Milleit; Cornelia Wiegand; Jana Hesse; Claudia M Klier; Magdalena Holub; Ingrid Holzer; Michael Berk; Patrick D McGorry; Heinrich Sauer; G Paul Amminger

Journal article

Effects of omega-3 PUFA on the vitamin E and glutathione antioxidant defense system in individuals at ultra-high risk of psychosis

Stefan Smesny, Berko Milleit, Miriam R Schaefer, Uta-Christina Hipler, Christine Milleit, Cornelia Wiegand, Jana Hesse, Claudia M Klier, Magdalena Holub, Ingrid Holzer, Michael Berk, Patrick D McGorry, Heinrich Sauer, G Paul Amminger

Prostaglandins Leukotrienes and Essential Fatty Acids | ELSEVIER SCI LTD | Published : 2015

DOI: 10.1016/j.plefa.2015.07.001

Abstract

BACKGROUND: Oxidative stress and impaired antioxidant defenses are reported in schizophrenia and are associated with disturbed neurodevelopment, brain structural alterations, glutamatergic imbalance, increased negative symptoms, and cognitive impairment. There is evidence that oxidative stress predates the onset of acute psychotic illness. Here, we investigate the effects of omega-3 PUFA on the vitamin E and glutathione antioxidant defense system (AODS). METHOD: In 64 help-seeking UHR-individuals (13-25 years of age), vitamin E levels and glutathione were investigated before and after 12 weeks of treatment with either 1.2g/d omega-3 (PUFA-E) or saturated fatty acids (SFA-E), with each condit..

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University of Melbourne Researchers

Paul Amminger Author Centre for Youth Mental Health

Michael Berk Author Psychiatry

Patrick McGorry Author Centre for Youth Mental Health

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Grants

Awarded by Stanley Medical Research Institute

Awarded by German Research Foundation (DFG)

Awarded by National Health and Medical Research Council of Australia

Awarded by NHMRC Senior Principal Research Fellowship

Funding Acknowledgements

The study was supported by a Stanley Medical Research Institute Grant (03T-315). In performing the analysis of oxidative stress markers, Dr Stefan Smesny was supported by the German Research Foundation (DFG), Grant Sm 68/3-1. Dr G Paul Amminger was supported by the National Health and Medical Research Council of Australia (No. 566529). Dr. Michael Berk is supported by a NHMRC Senior Principal Research Fellowship (No. 1059660). Dr Sherilyn Goldstone edited the final manuscript; Margit Kornsteiner and Jessica Slavik assisted with the erythrocyte fatty acid analysis; Kostas Papageorgiou assisted with psychiatric research assessments. We thank all of the participants and their families.