Development and validation of an epidemiologic case definition of epilepsy for use with routinely collected Australian health data
Michael Tan, Ian Wilson, Vanessa Braganza, Sophia Ignatiadis, Ray Boston, Vijaya Sundararajan, Mark J Cook, Wendy J D'Souza
Epilepsy & Behavior | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2015
OBJECTIVES: We report the diagnostic validity of a selection algorithm for identifying epilepsy cases. STUDY DESIGN AND SETTING: Retrospective validation study of International Classification of Diseases 10th Revision Australian Modification (ICD-10AM)-coded hospital records and pharmaceutical data sampled from 300 consecutive potential epilepsy-coded cases and 300 randomly chosen cases without epilepsy from 3/7/2012 to 10/7/2013. Two epilepsy specialists independently validated the diagnosis of epilepsy. A multivariable logistic regression model was fitted to identify the optimum coding algorithm for epilepsy and was internally validated. RESULTS: One hundred fifty-eight out of three hundre..View full abstract
Assoc. Prof. D'Souza has received travel, investigator-initiated, and speaker honoraria and has served on scientific advisory boards from UCB Pharma; has received educational grants from Novartis Pharmaceuticals, Pfizer Pharmaceuticals, and Sanofi-Synthelabo; has received educational, travel, and fellowship grants from GSK Neurology Australia; has served on scientific advisory boards; and has received honoraria from SciGen Pharmaceuticals. His institute has received research funding from GlaxoSmithKline, Scigen, Pfizer, Novartis, and UCB Pharma. The remaining authors have no conflict of interest.