Journal article
Ventilation/perfusion positron emission tomography - Based assessment of radiation injury to lung
S Siva, N Hardcastle, T Kron, M Bressel, J Callahan, MP MacManus, M Shaw, N Plumridge, RJ Hicks, D Steinfort, DL Ball, MS Hofman
International Journal of Radiation Oncology Biology Physics | Published : 2015
Abstract
Purpose To investigate 68Ga-ventilation/perfusion (V/Q) positron emission tomography (PET)/computed tomography (CT) as a novel imaging modality for assessment of perfusion, ventilation, and lung density changes in the context of radiation therapy (RT). Methods and Materials In a prospective clinical trial, 20 patients underwent 4-dimensional (4D)-V/Q PET/CT before, midway through, and 3 months after definitive lung RT. Eligible patients were prescribed 60 Gy in 30 fractions with or without concurrent chemotherapy. Functional images were registered to the RT planning 4D-CT, and isodose volumes were averaged into 10-Gy bins. Within each dose bin, relative loss in standardized uptake value (SUV..
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Funding Acknowledgements
Supported in part by a Priority-Drive Collaborative Cancer Research Scheme 2013 grant (APP 1060919) and by scholarship funding from the National Health and Medical Research Council to S. Siva.