Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets
Sylvia T Gunawan, Kristian Kempe, Thomas Bonnard, Jiwei Cui, Karen Alt, Lok S Law, Xiaowei Wang, Erik Westein, Georgina K Such, Karlheinz Peter, Christoph E Hagemeyer, Frank Caruso
ADVANCED MATERIALS | WILEY-V C H VERLAG GMBH | Published : 2015
Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.
Related Projects (4)
Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by Australian Research Council (ARC)
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by German Research Foundation
This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036) and supported by the Australian Research Council (ARC) under the Australian Laureate Fellowship (F.C., FL120100030), Super Science Fellowship (F.C., FS110200025), and Australian Future Fellowship (G.K.S., FT120100564) schemes, by the National Health and Medical Research Council (NHMRC) under Project Grant 1028145 and in part by the Victorian Government's OIS Program. K.K. is grateful to the Alexander von Humboldt-Foundation for a Feodor-Lynen Fellowship. K.A. is supported by the German Research Foundation (Al 1521/1-1). K.P. is a Principal Research Fellow of the NHMRC. C.E.H. is a National Heart Foundation Career Development Fellow (CR11M6066).