Relationship between characteristics on magnetic resonance imaging and motor outcomes in children with cerebral palsy and white matter injury
Susan M Reid, Michael R Ditchfield, Jenny Bracken, Dinah S Reddihough
RESEARCH IN DEVELOPMENTAL DISABILITIES | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015
In a population cohort of children with white matter injury (WMI) and cerebral palsy (CP), we aimed to describe the magnetic resonance imaging (MRI) characteristics, identify key structure-function relationships, and classify the severity of WMI in a clinically relevant way. Stratified on MRI laterality/symmetry, variables indicating the extent and location of cerebral abnormalities for 272 children with CP and WMI on chronic-phase MRI were related to gross motor function and motor topography using univariable and multivariable approaches. We found that symmetrical involvement, severe WM loss in the hemispheres and corpus callosum, and cerebellar involvement were the strongest predictors of ..View full abstract
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Awarded by Australian National Health and Medical Research Council
Assessment of the MRI scans was funded by the William Henry and Vera Ellen Houston Memorial Trust Fund and the CP Alliance, and the study was supported by funds from the Lorenzo and Pamela Galli Trust. The Victorian Department of Health and the Victorian Medical Insurance Agency assisted with funding to run the Victorian Cerebral Palsy Register. Infrastructure support was provided by the Victorian Government's Operational Infrastructure Support Program and the first author received salary support through an Early Career Fellowship #1072442 (2014-2017) from the Australian National Health and Medical Research Council.