Journal article

Natural killer cell education does not affect the magnitude of granzyme B delivery to target cells by antibody-dependent cellular cytotoxicity

Gamze Isitman, Irene Lisovsky, Alexandra Tremblay-McLean, Matthew S Parsons, Naglaa H Shoukry, Mark A Wainberg, Julie Bruneau, Nicole F Bernard


University of Melbourne Researchers


Awarded by Canadian Institutes for Health Research (CIHR)

Awarded by CIHR

Awarded by Alberta Innovates

Funding Acknowledgements

This study received support from the Canadian Institutes for Health Research (CIHR) MOP-123800 and THA-118628 and the Fonds de Recherche du Quebec-Sante (FRQ-S) AIDS and Infectious Diseases Network. G.I. was supported by a postdoctoral scholarship from Canadian HIV Trials Network and CIHR, I.L. was supported by a Ph.D. scholarship from FRQ-S and CIHR. M.P. was supported by a postdoctoral scholarship from CIHR. N.B. is a member of the RI-MUHC, an institution funded in part by the FRQ-S.G.I., N.F.B. and M.S.P. conceived and designed the study. G.I., I.L. and A.T.M. performed the experiments and analysed the results described in the manuscript. G.I. and N.F.B. wrote the manuscript with I.L., M.A.T., N.S., J.B., M.A.W. providing comments and editing suggestions. N.S. and J.B. provided samples from the study participants included in the study. M.A.W. was the lead on obtaining the THA-118628 funding from CIHR, which partially supported the research included in the manuscript and provided support and direction on this study.