Evaluation of biomarkers of cell cycle arrest and inflammation in prediction of dialysis or recovery after kidney transplantation
Timothy J Pianta, Philip W Peake, John W Pickering, Michaela Kelleher, Nicholas A Buckley, Zoltan H Endre
Transplant International | WILEY | Published : 2015
Early prediction of delayed graft function (DGF) after kidney transplantation would facilitate patient management. Cell cycle arrest and inflammation are implicated in the pathogenesis of DGF. We assessed the utility of two novel acute kidney injury (AKI) biomarkers, urinary tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7), and five inflammatory markers to predict DGF following deceased-donor kidney transplantation. Serial urine concentrations of TIMP-2 and IGFBP7 were measured immediately after transplantation in 56 recipients along with vascular endothelial growth factor-A (VEGF-A), macrophage migration inhibitory factor (MIF), mon..View full abstract
Awarded by Australian National Health and Medical Research Council
Funding for this study included Australian National Health and Medical Research Council project grant 1011772. TJP gratefully acknowledges the financial support of the Jacquot Research Entry Scholarship and a UNSW Australian Postgraduate Award.