Journal article
Cyclic AMP inhibits expression of D-Type cyclins and cdk4 and induces p27(Kip1) in G-CSF-Treated NFS-60 cells
AC Ward, XF Csar, BW Hoffmann, JA Hamilton
Biochemical and Biophysical Research Communications | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 1996
Abstract
The addition of cAMP inhibits G-CSF-mediated proliferation and suppresses pRB phosphorylation in NFS-60 cells. We show that the latter could be attributed to different effects of cAMP in these cells: (i) down-regulation of the levels of cyclins D2 and D3, and cdk4, and (ii) induction of the p27(Kip1) inhibitor of cdk4.