Journal article

INTERLEUKIN-4 INHIBITS HUMAN SMOOTH-MUSCLE CELL-PROLIFERATION

PK VADIVELOO, HR STANTON, FW COCHRAN, JA HAMILTON

ARTERY | ARTERY PUBLISHING | Published : 1994

Abstract

Although proliferation of smooth muscle cells is a key event in the pathogenesis of atherosclerosis, the signals which regulate this proliferation are not fully understood. It is likely that proliferation is regulated by cytokines released by cells found in the plaque, such as T cells. In this study we report that the T cell-derived cytokine, interleukin-4 (IL-4), can inhibit proliferation of cultured human umbilical artery smooth muscle cells. Maximum inhibitory effect was achieved at IL-4 concentrations of 20 U/ml or greater. In addition, the data showed that IL-4 acted early in the G1 phase of the cell cycle, thereby preventing cells from entering S phase. The mechanism of IL-4 inhibition..

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