REGULATION OF PROSTAGLANDIN AND PLASMINOGEN-ACTIVATOR PRODUCTION BY MOUSE PERITONEAL-MACROPHAGES

Abstract

Prostaglandin E (PGE) and plasminogen activator (PA) were assayed in cultures of the same mouse peritoneal macrophage populations. Resident macrophages produced more PGE but less PA than elicited macrophages. There are also differences even among the elicited macrophage populations in that starch-elicited cells have higher PGE but lower PA levels than do the thioglycollate-elicited cells. During studies of the in vitro regulation by macrophages of their PGE and PA levels, marked differences were observed depending on the agent added to the macrophages. Endotoxin raised the PGE levels of resident and starch-elicited macrophages while either reducing slightly or having no effect on the PA acti..