STIMULATION OF PLASMINOGEN-ACTIVATOR IN OSTEOBLAST-LIKE CELLS BY BONE-RESORBING HORMONES
JA HAMILTON, SR LINGELBACH, NC PARTRIDGE, TJ MARTIN
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | Published : 1984
Hormonal control of plasminogen activator (PA) was studied in clonal rat osteogenic sarcoma cells which are phenotypically osteoblast, and in osteoblast-rich rat bone cell cultures. The bone-resorbing hormones (parathyroid hormone, prostaglandin E2, epidermal growth factor and 1,25-dihydroxyvitamin D3) stimulated PA activity in both cell types. The relative efficacies of vitamin D metabolites and of prostanoids reflect their relative potencies as stimulators of bone resorption.