MACROPHAGE TUMOR-CELL LINE AND PLASMINOGEN ACTIVATOR - POTENTIAL MODEL SYSTEM FOR MACROPHAGE REGULATION OF ENZYME-PRODUCTION
JA HAMILTON, P RALPH, MAS MOORE
JOURNAL OF EXPERIMENTAL MEDICINE | ROCKEFELLER UNIV PRESS | Published : 1978
The macrophage cell line, RAW264.10, synthesizes and secretes plasminogen activator. Production of this enzyme is inhibited by low concentrations of glucocorticoids and increased by phorbol myristate acetate. It is proposed that this line could be a suitable model for the regulation of enzyme synthesis by mouse peritoneal macrophages.