Analysis of Hereditary Nonpolyposis Colorectal Cancer in Malay Cohorts using Immunohistochemical Screening.
Wan Khairunnisa Wan Juhari, Wan Faiziah Wan Abdul Rahman, Ahmad Shanwani Mohd Sidek, Muhammad Radzi Abu Hassan, Khairul Bariah Ahmad Amin Noordin, Andee Dzulkarnaen Zakaria, Finlay Macrae, Bin Alwi Zilfalil
Asian Pacific Journal of Cancer Prevention | Published : 2015
BACKGROUND: Lynch syndrome (LS) is an inherited predisposition to colorectal, endometrial (uterine) and other cancers. Although most cancers are not inherited, about 5 percent (%) of people who have colorectal or endometrial cancer have the Lynch syndrome. It involves the alteration of mismatch repair (MMR) genes; MLH1, MSH2, MSH6 or PMS2. In this study, we analyzed the expression of MMR proteins in colorectal cancer in a Malay cohort by immunohistochemistry. MATERIALS AND METHODS: A total of 17 patients were selected fulfilling one of the Bethesda criteria: colorectal cancer diagnosed in a patient aged less than 50 years old, having synchronous and metachronous colorectal cancer or with a s..View full abstract