Establishment of functional influenza virus-specific CDS T cell memory pools after intramuscular immunization
Zhongfang Wang, Brendon Y Chua, Javier Vega Ramos, Sergio M Quinones Parra, Emily Fairmaid, Lorena E Brown, David C Jackson, Katherine Kedzierska
VACCINE | ELSEVIER SCI LTD | Published : 2015
The emergence of the avian-origin influenza H7N9 virus and its pandemic potential has highlighted the ever-present need to develop vaccination approaches to induce cross-protective immunity. In this study, we examined the establishment of cross-reactive CD8(+) T cell immunity in mice following immunization with live A/Puerto Rico/8/1934 (PR8; H1N1) influenza virus via two non-productive inoculation routes. We found that immunization via the intramuscular (IM) route established functional influenza-virus specific memory CD8(+) T cell pools capable of cross-reactive recall responses. Epitope-specific primary, memory and recall CD8(+) T-cell responses induced by the IM route, highly relevant to..View full abstract
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Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by NHMRC
The work was supported by Australian National Health and Medical Research Council (NHMRC) Project Grant to KK (AI1008854), NHMRC Program Grant to KK, LEB and DCJ (AI APP1071916). KK is an NHMRC CDF2 Fellow; ZW is an NHMRC China-Australia Exchange Fellow, DCJ is an NHMRC SPRF Fellow.