Effect of age at onset of schizophrenia on white matter abnormalities
Marinos Kyriakopoulos, Rocio Perez-Iglesias, James B Woolley, Richard AA Kanaan, Nora S Vyas, Gareth J Barker, Sophia Frangou, Philip K McGuire
The British Journal of Psychiatry | CAMBRIDGE UNIV PRESS | Published : 2009
BACKGROUND: The pattern of brain morphological changes at the early stages of schizophrenia may depend on the age at onset of illness; in children and adolescents with schizophrenia, grey matter deficits are seen in the parietal lobe whereas in individuals with adult onset these are more widespread. AIMS: To examine whether white matter is similarly affected. METHOD: Diffusion tensor imaging was used to compare fractional anisotropy measures in individuals with adolescent-onset (n = 17) and adult-onset schizophrenia (n = 17) with those in age- and gender-matched controls. RESULTS: Compared with their respective controls, individuals with adolescent-onset schizophrenia showed fractional aniso..View full abstract
Awarded by Guys & St Thomas' Charitable Foundation
Awarded by GlaxoSmithKline (GSK)
This study was supported by grants from Guys & St Thomas' Charitable Foundation (G041001) and GlaxoSmithKline (GSK 084) to P.K.M. and a grant from the National Alliance of Research on Schizophrenia and Depression to S.F. R.A.A.K. is supported by the Wellcome Trust.