Journal article

Inner retinal change in a novel rd1-FTL mouse model of retinal degeneration

Ursula Greferath, Emily E Anderson, Andrew I Jobling, Kirstan A Vessey, Gemma Martinez, Robb U de Iongh, Michael Kalloniatis, Erica L Fletcher

FRONTIERS IN CELLULAR NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2015

Abstract

While photoreceptor loss is the most devastating result of inherited retinal degenerations such as retinitis pigmentosa, inner retinal neurons also undergo significant alteration. Detailing these changes has become important as many vision restorative therapies target the remaining neurons. In this study, the rd1-Fos-Tau-LacZ (rd1-FTL) mouse model was used to explore inner retinal change at a late stage of retinal degeneration, after the loss of photoreceptor nuclei. The rd1-FTL model carries a mutation in the phosphodiesterase gene, Pde6b, and an axonally targeted transgenic beta galactosidase reporter system under the control of the c-fos promoter. Retinae of transgenic rd1-FTL mice and co..

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Grants

Awarded by NHMRC


Funding Acknowledgements

The authors would like to thank Dr. Nupur Nag for her expertise and help with some of the retinal immunohistochemistry and figure production. This work was supported by the NHMRC project grant (APP1021042) to EF, by Retina Australia, and the Australian Research Council, through its Special Research Initiative in Bionic Vision Science and Technology grant to Bionic Vision Australia.