Innate Immunity and the Inter-exposure Interval Determine the Dynamics of Secondary Influenza Virus Infection and Explain Observed Viral Hierarchies
Pengxing Cao, Ada WC Yan, Jane M Heffernan, Stephen Petrie, Robert G Moss, Louise A Carolan, Teagan A Guarnaccia, Anne Kelso, Ian G Barr, Jodie McVernon, Karen L Laurie, James M McCaw
PLOS COMPUTATIONAL BIOLOGY | PUBLIC LIBRARY SCIENCE | Published : 2015
Influenza is an infectious disease that primarily attacks the respiratory system. Innate immunity provides both a very early defense to influenza virus invasion and an effective control of viral growth. Previous modelling studies of virus-innate immune response interactions have focused on infection with a single virus and, while improving our understanding of viral and immune dynamics, have been unable to effectively evaluate the relative feasibility of different hypothesised mechanisms of antiviral immunity. In recent experiments, we have applied consecutive exposures to different virus strains in a ferret model, and demonstrated that viruses differed in their ability to induce a state of ..View full abstract
Awarded by Australian Government National Health and Medical Research Council Career Development Award
Awarded by Australian Research Council Future Fellowship
The Melbourne WHO Collaborating Centre for Reference and Research on Influenza at the Peter Doherty Institute is supported by the Australian Government Department of Health (http://www.health.gov.au/). JM was supported by a Australian Government National Health and Medical Research Council Career Development Award (1061321) (http://www.nhmrc.gov.au/). JMM was supported by an Australian Research Council Future Fellowship (110100250) (http://www.arc.gov.au/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.