Journal article

The effect of intraocular and intracranial pressure on retinal structure and function in rats

Da Zhao, Zheng He, Algis J Vingrys, Bang V Bui, Christine TO Nguyen



An increasing number of studies indicate that the optic nerve head of the eye is sensitive not only to changes in intraocular pressure (IOP), but also to intracranial pressure (ICP). This study examines changes to optic nerve and retinal structure in a rat model in response to a range of IOP and ICP levels using optical coherence tomography. Furthermore, we examine the functional sequelae of these structural changes by quantifying the effect of pressure changes on the electroretinogram. IOP elevation (10-90 mmHg) induces progressive deformation of the optic nerve head and retinal surface (P < 0.05), compression of the retina (P < 0.05) and bipolar cell (b-wave), and retinal ganglion cell (sc..

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Awarded by University of Melbourne

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

Research Collaboration Grant 501098, University of Melbourne (CTON, BVB, ZH, AJV). National Health and Medical Research Council (NHMRC) Grants 1046203 (BVB, AJV), Melbourne Neuroscience Institute Fellowship (CTON).