Book Chapter

Exercise and Gene Expression

Mark Hargreaves

MOLECULAR AND CELLULAR REGULATION OF ADAPTATION TO EXERCISE | Progress in Molecular Biology and Translational Science | ELSEVIER ACADEMIC PRESS INC | Published : 2015

Abstract

Acute and transient changes in gene transcription following a single exercise bout, if reinforced by repeated exercise stimuli, result in the longer lasting effects on protein expression and function that form the basis of skeletal muscle training adaptations. Changes in skeletal muscle gene expression occur in response to multiple stimuli associated with skeletal muscle contraction, various signaling kinases that respond to these stimuli, and numerous downstream pathways and targets of these kinases. In addition, DNA methylation, histone acetylation and phosphorylation, and micro-RNAs can alter gene expression via epigenetic mechanisms. Contemporary studies rely upon "big omics data," in co..

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University of Melbourne Researchers