Contrast-enhanced ultrasound evaluation of renal microcirculation in sheep

AG Schneider; P Calzavacca; A Schelleman; T Huynh; M Bailey; C May; R Bellomo

Journal article

Contrast-enhanced ultrasound evaluation of renal microcirculation in sheep

AG Schneider, P Calzavacca, A Schelleman, T Huynh, M Bailey, C May, R Bellomo

Intensive Care Medicine Experimental | Published : 2014

DOI: 10.1186/s40635-014-0033-y

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Abstract

Background: Contrast-enhanced ultrasonography (CEUS) is a novel imaging modality to estimate microvascular perfusion. We aimed to assess renal cortical microcirculatory changes by CEUS during pharmacologically or mechanically induced modifications of renal blood flow (RBF) in experimental animals. Methods: We implanted invasive transit-time Doppler flow probes and a vascular occluder around the renal artery in six Merino sheep. After induction of general anaesthesia, renal CEUS studies with destruction-replenishment sequences were performed at baseline and after different interventions aimed at modifying RBF. First, we administered angiotensin II (AngII) to achieve a 25% (AngII 25%) and 50% ..

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University of Melbourne Researchers

Clive May Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (Project Grant 1009280) and the Victorian Government's Operational Infrastructure Support Program. C.N. May was supported by a NHMRC Research Fellowship.