Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop

Maria C Tanzer; Anne Tripaydonis; Andrew I Webb; Samuel N Young; Leila N Varghese; Cathrine Hall; Warren S Alexander; Joanne M Hildebrand; John Silke; James M Murphy

Journal article

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop

Maria C Tanzer, Anne Tripaydonis, Andrew I Webb, Samuel N Young, Leila N Varghese, Cathrine Hall, Warren S Alexander, Joanne M Hildebrand, John Silke, James M Murphy

Biochemical Journal | PORTLAND PRESS LTD | Published : 2015

DOI: 10.1042/BJ20150678

University of Melbourne Researchers

Andrew Webb Author Medical Biology (W.E.H.I.)

James Murphy Author Medical Biology (W.E.H.I.)

John Silke Author Medical Biology (W.E.H.I.)

Joanne Hildebrand Author Medical Biology (W.E.H.I.)

Warren Alexander Author Medical Biology (W.E.H.I.)

Grants

Awarded by National Health and Medical Research Council of Australia

Awarded by Australian Research Council

Awarded by National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia [grant numbers 1016647, 1057888, 1057905, 1046010 and 1058344 (to W.S.A.), 541951 (to J.M.H.), and 541901 and 1058190 (to J.S.)]; the Australian Research Council Future Fellowship [grant number FT100100100 (to J.M.M.)]; the Victorian International Research Scholarship (to M.C.T.); the Victorian State Government Operational Infrastructure Support; and the National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme [grant number 9000220].