Journal article

Excitatory orexinergic innervation of rat nucleus incertus - Implications for ascending arousal, motivation and feeding control

Anna Blasiak, Marcin Siwiec, Agnieszka Grabowiecka, Tomasz Blasiak, Anna Czerw, Ewa Blasiak, Alan Kania, Zenon Rajfur, Marian H Lewandowski, Andrew L Gundlach

Neuropharmacology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015


Orexin/hypocretin peptides play a central role in the integrated control of feeding/reward and behavioural activation, principally via interactions with other neural systems. A brainstem area involved in behavioural activation is the nucleus incertus (NI), located in the posterior ventromedial central grey. Several studies have implicated NI in control of arousal/stress and reward/feeding responses. Orexin receptor mRNA expression identifies NI as a putative target of orexin modulation. Therefore, in this study we performed neural tract-tracing and immunofluorescence staining to characterise the orexinergic innervation of NI. Our results indicate a convergent innervation of the NI area by di..

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University of Melbourne Researchers


Awarded by Polish Ministry of Science and Higher Education

Awarded by National Science Centre

Awarded by EU

Funding Acknowledgements

This work was supported by a research grant from the Polish Ministry of Science and Higher Education (N N303 569939 to T.B., A.B. and A.L.G.); a research grant from The National Science Centre (DEC-2012/05/D/NZ4/02984 to A.B. and A.L.G.) and an EU-funded Exchange Program (FP7-PEOPLE-IRSES PIRSES-GA-2012-318997 NEUREN project to A.B. and A.L.G.).