Excitatory orexinergic innervation of rat nucleus incertus - Implications for ascending arousal, motivation and feeding control
Anna Blasiak, Marcin Siwiec, Agnieszka Grabowiecka, Tomasz Blasiak, Anna Czerw, Ewa Blasiak, Alan Kania, Zenon Rajfur, Marian H Lewandowski, Andrew L Gundlach
Neuropharmacology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015
Orexin/hypocretin peptides play a central role in the integrated control of feeding/reward and behavioural activation, principally via interactions with other neural systems. A brainstem area involved in behavioural activation is the nucleus incertus (NI), located in the posterior ventromedial central grey. Several studies have implicated NI in control of arousal/stress and reward/feeding responses. Orexin receptor mRNA expression identifies NI as a putative target of orexin modulation. Therefore, in this study we performed neural tract-tracing and immunofluorescence staining to characterise the orexinergic innervation of NI. Our results indicate a convergent innervation of the NI area by di..View full abstract
Awarded by Polish Ministry of Science and Higher Education
Awarded by National Science Centre
Awarded by EU
This work was supported by a research grant from the Polish Ministry of Science and Higher Education (N N303 569939 to T.B., A.B. and A.L.G.); a research grant from The National Science Centre (DEC-2012/05/D/NZ4/02984 to A.B. and A.L.G.) and an EU-funded Exchange Program (FP7-PEOPLE-IRSES PIRSES-GA-2012-318997 NEUREN project to A.B. and A.L.G.).