Journal article

Activation of relaxin family receptor 1 from different mammalian species by relaxin peptide and small-molecule agonist ML290

Zaohua Huang, Courtney Myhr, Ross AD Bathgate, Brian A Ho, Amaya Bueno, Xin Hu, Jingbo Xiao, Noel Southall, Elena Barnaeva, Irina U Agoulnik, Juan J Marugan, Marc Ferrer, Alexander I Agoulnik

FRONTIERS IN ENDOCRINOLOGY | FRONTIERS MEDIA SA | Published : 2015

Grants

Awarded by James and Esther King Biomedical Research Program


Awarded by National Cancer Institute grant


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

The authors thank Dr. O. David Sherwood, University of Illinois, for providing porcine relaxin; Prof. John D. Wade, Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia, for providing mouse relaxin peptide; Corthera, Inc. (San Mateo, CA, USA) for providing recombinant human relaxin and Sharon Layfield and Tania Ferraro for technical assistance with studies at the Florey and Shashank Pawitwar and Supurna Dhar for their help in cloning rabbit and guinea pig receptors. This research was supported by Florida Department of Health, James and Esther King Biomedical Research Program grant 3KFO1, and National Cancer Institute grant 1U01CA177711 (AA). Research at the Florey was supported by National Health and Medical Research Council of Australia project grants 628427 and 1043750 and by the Victorian Government Operational Infrastructure Support Program. RADB is a recipient of an NHMRC Research Fellowship. BH is a recipient of a MARC U*STAR program fellowship at the Florida International University.