Interleukin-21-Producing CD4( ) T Cells Promote Type 2 Immunity to House Dust Mites
Jonathan M Coquet, Martijn J Schuijs, Mark J Smyth, Kim Deswarte, Rudi Beyaert, Harald Braun, Louis Boon, Gunilla B Karlsson Hedestam, Steven L Nutt, Hamida Hammad, Bart N Lambrecht
Immunity | CELL PRESS | Published : 2015
Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17 and innate lymphoid cells also in regulating airway inflammation. Herein, we have demonstrated profound interleukin-21 (IL-21) production after house dust mite (HDM)-driven asthma by using T cell receptor (TCR) transgenic mice reactive to Dermatophagoides pteronyssinus 1 and an IL-21GFP reporter mouse. IL-21-producing cells in the mediastinal lymph node (mLN) bore characteristics of T follicular helper (Tfh) cells, whereas IL-21(+) cells in the lung did not express CXCR5 (a chemokine receptor expressed by Tfh cells) and were distinct from effector Th2 or Th17 cells. Il21r(-/-) mice developed reduced t..View full abstract
Awarded by National Health and Medical Research Council of Australia
Research was funded by the project, "Mechanisms for the Development of Allergy (MeDALL),'' a Seventh Framework Program (FP7) of the European Union (2011-2014). S.L.N. is supported by the National Health and Medical Research Council of Australia (1054925). B.N.L. was supported by an ERC consolidator grant and a University of Gent GROUP-ID MRP grant. B.N.L., H.H., and R.B. are supported by several FWO grants. J.M.C. is supported by a Swedish Research Council Young Investigator Grant.