Journal article

Interleukin-21-Producing CD4( ) T Cells Promote Type 2 Immunity to House Dust Mites

Jonathan M Coquet, Martijn J Schuijs, Mark J Smyth, Kim Deswarte, Rudi Beyaert, Harald Braun, Louis Boon, Gunilla B Karlsson Hedestam, Steven L Nutt, Hamida Hammad, Bart N Lambrecht

Immunity | CELL PRESS | Published : 2015

Abstract

Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17 and innate lymphoid cells also in regulating airway inflammation. Herein, we have demonstrated profound interleukin-21 (IL-21) production after house dust mite (HDM)-driven asthma by using T cell receptor (TCR) transgenic mice reactive to Dermatophagoides pteronyssinus 1 and an IL-21GFP reporter mouse. IL-21-producing cells in the mediastinal lymph node (mLN) bore characteristics of T follicular helper (Tfh) cells, whereas IL-21(+) cells in the lung did not express CXCR5 (a chemokine receptor expressed by Tfh cells) and were distinct from effector Th2 or Th17 cells. Il21r(-/-) mice developed reduced t..

View full abstract

University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

Research was funded by the project, "Mechanisms for the Development of Allergy (MeDALL),'' a Seventh Framework Program (FP7) of the European Union (2011-2014). S.L.N. is supported by the National Health and Medical Research Council of Australia (1054925). B.N.L. was supported by an ERC consolidator grant and a University of Gent GROUP-ID MRP grant. B.N.L., H.H., and R.B. are supported by several FWO grants. J.M.C. is supported by a Swedish Research Council Young Investigator Grant.