Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event

Victoria Lewis; Vanessa A Johanssen; Peter J Crouch; Genevieve M Klug; Nigel M Hooper; Steven J Collins

Journal article

Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event

Victoria Lewis, Vanessa A Johanssen, Peter J Crouch, Genevieve M Klug, Nigel M Hooper, Steven J Collins

Cellular and Molecular Life Sciences | SPRINGER BASEL AG | Published : 2016

DOI: 10.1007/s00018-015-2022-z

Download PDF

University of Melbourne Researchers

Steven Collins Author Medicine - Royal Melbourne Hospital

Peter Crouch Author Pharmacology and Therapeutics

Vicki Lewis Author Medicine - Royal Melbourne Hospital

Related Projects (4)

Prion Protein Cleavage.

Prion diseases, including Bovine Spongiform encephalopathy (“mad cow disease”) and Creutzfeldt-Jakob Disease in humans are transmissible and..

Diseases Of The Ageing Brain

The Neurodegeneration Program is discovering the basic pathways that cause Alzheimer’s disease and related diseases of the aging brain; from..

Determining Normal Prion Protein Function, Emphasising The Role Played By Protein Cleavage, And Also Defining The Relationship Between Surveillance Intensity And Annual Sporadic Cjd Incidence

As a neurologist undertaking research into prion diseases over an extended period, I have been able to lead and participate in many projects..

Discovering 'C3': Characterization Of A Novel Prion Protein Cleavage Event.

Grants

Awarded by Australian Government National Health and Medical Research Council (NHMRC)

Awarded by Medical Research Council of Great Britain

Awarded by Medical Research Council

Funding Acknowledgements

The authors thank Associate Professor Victoria Lawson for her kind gift of the RK13 cells, Professor Charles Weissmann for the Tga20 mice, and the Victorian Brain Bank Network for their assistance in human control brain tissue sampling. This work was supported by an Australian Government National Health and Medical Research Council (NHMRC) Program Grant #628946 (SJC, VL, VJ), Practitioner Fellowship #1005816 (SJC), Training Fellowship #567123 (VL), R. D. Wright Fellowship (CDF2) (PJC) and Project Grant #1061550 (PJC), a University of Melbourne Early Career Researcher Fellowship (VL), the CJD Support Group Network (VL), and the Medical Research Council of Great Britain (G0802189) (NMH).