Identification of novel osteochondrosis Associated genes
Michiko Mirams, Babatunde A Ayodele, Liliana Tatarczuch, Frances M Henson, Charles N Pagel, Eleanor J Mackie
JOURNAL OF ORTHOPAEDIC RESEARCH | WILEY-BLACKWELL | Published : 2016
During the early stages of articular osteochondrosis, cartilage is retained in subchondral bone, but the pathophysiology of this condition of growing humans and domestic animals is poorly understood. A subtractive hybridization study was undertaken to compare gene expression between the cartilage of early experimentally induced equine osteochondrosis lesions and control cartilage. Of the many putative differentially expressed genes identified, eight were confirmed by quantitative PCR analysis as differentially expressed, in addition to those already known to be associated with early lesions. Genes encoding vacuolar H(+)-ATPase V0 subunit d2 (ATP6V0D2), cathepsin K, integrin-binding sialoprot..View full abstract
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Awarded by Racing Victoria Pty Ltd
Awarded by Rural Industries Research and Development Corporation
Grant sponsor: Australian Research Council and Racing Victoria Pty Ltd; Grant number: LP0348867; Grant sponsor: Rural Industries Research and Development Corporation; Grant number: PRJ-000216.