Journal article

The role of CaMKII in diabetic heart dysfunction

Lorna Daniels, James R Bell, Lea MD Delbridge, Fiona J McDonald, Regis R Lamberts, Jeffrey R Erickson

HEART FAILURE REVIEWS | SPRINGER | Published : 2015

Abstract

Diabetes mellitus (DM) is an increasing epidemic that places a significant burden on health services worldwide. The incidence of heart failure (HF) is significantly higher in diabetic patients compared to non-diabetic patients. One underlying mechanism proposed for the link between DM and HF is activation of calmodulin-dependent protein kinase (CaMKIIδ). CaMKIIδ mediates ion channel function and Ca(2+) handling during excitation-contraction and excitation-transcription coupling in the myocardium. CaMKIIδ activity is up-regulated in the myocardium of diabetic patients and mouse models of diabetes, where it promotes pathological signaling that includes hypertrophy, fibrosis and apoptosis. Phar..

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