CD11d integrin blockade reduces the systemic inflammatory response syndrome after traumatic brain injury in rats.
Lynne C Weaver, Feng Bao, Gregory A Dekaban, Todd Hryciw, Sandy R Shultz, Donald P Cain, Arthur Brown
Experimental Neurology | Published : 2015
Traumatic CNS injury triggers a systemic inflammatory response syndrome (SIRS), in which circulating inflammatory cells invade body organs causing local inflammation and tissue damage. We have shown that the SIRS caused by spinal cord injury is greatly reduced by acute intravenous treatment with an antibody against the CD11d subunit of the CD11d/CD18 integrin expressed by neutrophils and monocyte/macrophages, a treatment that reduces their efflux from the circulation. Traumatic brain injury (TBI) is a frequently occurring injury after motor vehicle accidents, sporting and military injuries, and falls. Our studies have shown that the anti-CD11d treatment diminishes brain inflammation and oxid..View full abstract
Awarded by Canadian Institutes of Health Research