Imaging modalities in high-grade gliomas: Pseudoprogression, recurrence, or necrosis?
I Caroline, MA Rosenthal
JOURNAL OF CLINICAL NEUROSCIENCE | ELSEVIER SCI LTD | Published : 2012
High grade gliomas (HGG) frequently recur regardless of treatment. Radiological detection of progressive disease (PD) is challenging due to the possibility of therapy-related MRI changes including: pseudoprogression (PP) and radiation necrosis (RN). Both may mimic PD. We undertook a literature review to examine existing data regarding imaging modalities and their ability to distinguish between PP, RN and PD. The review revealed 26 articles comparing the value of imaging modalities used to differentiate PP, RN and PD. Overall, conventional MRI and (18)fluorine-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) were more sensitive, while thallium single photon emission CT (SPECT) ..View full abstract