Journal article

dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

Y Estornes, F Toscano, F Virard, G Jacquemin, A Pierrot, B Vanbervliet, M Bonnin, N Lalaoui, P Mercier-Gouy, Y Pacheco, B Salaun, T Renno, O Micheau, S Lebecque

Cell Death & Differentiation | NATURE PUBLISHING GROUP | Published : 2012

University of Melbourne Researchers


Awarded by ANR (Agence Nationale de la Recherche)

Funding Acknowledgements

We thank our colleagues who provided reagents, especially Patrick Mehlen for the Bcl-2-expressing plasmid, Wayne Fairbrother for the gift of Smac mimetic BV6, Isabelle Grosjean for her assistance with cultures, Stephanie Brunet-Manquat and Isabelle Durand for their support with flow cytometry, Jean-Paul Pais De Barros for assistance with size-exclusion chromatography, and our colleagues in the laboratory for their restless support and encouragement. The Canceropole Lyon Auvergne Rhone-Alpes (CLARA) funded the work and SL was supported by a grant from the Hospices Civils de Lyon. OM was supported by grants from the ANR (Agence Nationale de la Recherche 07-PCV-0031) and the European Community (ApopTrain Marie Curie RTN). GJ and NL were supported by fellowships from the Ligue Nationale contre le Cancer and a joint INSERM and Conseil Regional de Bourgogne fellowship, respectively. We gratefully acknowledge the help and advice of Nicolas Foray.