Journal article
Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells
Guillaume Jacquemin, Virginie Granci, Anne Sophie Gallouet, Najoua Lalaoui, Aymeric Morle, Elisabetta Iessi, Alexandre Morizot, Carmen Garrido, Thierry Guillaudeux, Olivier Micheau
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | FERRATA STORTI FOUNDATION | Published : 2012
Abstract
BACKGROUND: Non-Hodgkin's B-cell lymphomas account for approximately 70% of B-cell lymphomas. While its incidence is dramatically increasing worldwide, the disease is still associated with high morbidity due to ineffectiveness of conventional therapies, creating an urgent need for novel therapeutic approaches. Unconventional compounds, including polyphenols and the cytokine TRAIL, are being extensively studied for their capacity to restore apoptosis in a large number of tumors, including lymphomas. DESIGN AND METHODS: Molecular mechanisms of TRAIL-resistance and reactivation of the apoptotic machinery by quercetin in non-Hodgkin's lymphoma cell lines were determined by Hoescht, flow cytometr..
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Awarded by ANR (Agence Nationale de la Recherche)
Funding Acknowledgements
this work was supported by grants from the Conseil Regional de Bourgogne, the INCa (Institut National du Cancer), Canceropole Grand-Est, ANR (Agence Nationale de la Recherche, ANR- 07-PCV-0031), and the European Community (ApopTrain Marie Curie RTN). GJ and VG were supported by fellowships from the Ligue Nationale contre le Cancer and the INCa.