Journal article
The CD14 C-260T single nucleotide polymorphism (SNP) modulates monocyte/macrophage activation in treated HIV-infected individuals
R Rajasuriar, YY Kong, R Nadarajah, NK Abdullah, T Spelman, MY Yuhana, S Ponampalavanar, A Kamarulzaman, SR Lewin
Journal of Translational Medicine | BMC | Published : 2015
Abstract
Background: HIV-infected individuals have an increased risk of cardiovascular disease (CVD). T-allele carriers of the CD14 C-260T single-nucleotide polymorphism (SNP) have reported increased expression of the LPS-binding receptor, CD14 and inflammation in the general population. Our aim was to explore the relationship of this SNP with monocyte/macrophage activation and inflammation and its association with sub-clinical atherosclerosis in HIV-infected individuals. Methods: Patients with no pre-existing CVD risk factors on suppressive antiretroviral therapy were recruited from University Malaya Medical Centre, Malaysia (n = 84). The CD14 C-260T and TLR4 SNPs, Asp299Gly and Thr399Ile were genot..
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Awarded by Ministry of Higher Education, Malaysia
Funding Acknowledgements
We thank Chong Meng Li and the clinicians at the Infectious Diseases Unit, University Malaya Medical Centre for assisting with recruitment and the patients for participating in this study. This work was funded by the Ministry of Higher Education, Malaysia and University of Malaya High Impact Research Grant (H-20001-E000001) and performed at the Immunotherapeutics Laboratory (ITL), University of Malaya.