Infarct Volume-Based Subgroup Selection in Acute Ischemic Stroke Trials
Anna Kufner, Anke Wouters, Luc Bracoud, Rico Laage, Armin Schneider, Wolf-Ruediger Schaebitz, Marc Hermier, Vincent Thijs, Jochen B Fiebach
Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015
BACKGROUND AND PURPOSE: We investigated whether hyperintensities with a diameter of at least 3, 3.5, and 4 cm and visible on at least 3 slices on diffusion-weighted imaging enables patient selection with an infarct volume of ≥15 mL. METHODS: Consecutive acute stroke patients were screened for the AXIS2 trial and examined according to a standardized magnetic resonance imaging protocol in 65 sites. Diffusion-weighted lesion diameters were measured and compared with volumetric assessments. RESULTS: Out of 238 patients, 86.2% (N=206) had infarct diameter of at least 3 cm. Volumetric assessments showed infarct volume of ≥15 mL in 157 patients. A cut-off value of 3 cm led to 96.8% sensitivity and ..View full abstract
Awarded by Federal Ministry of Education and Research via the grant Center for Stroke Research Berlin
The research leading to these results received funding from the Federal Ministry of Education and Research via the grant Center for Stroke Research Berlin (01EO0801 and 01EO1301).