Journal article

Infarct Volume-Based Subgroup Selection in Acute Ischemic Stroke Trials

Anna Kufner, Anke Wouters, Luc Bracoud, Rico Laage, Armin Schneider, Wolf-Ruediger Schaebitz, Marc Hermier, Vincent Thijs, Jochen B Fiebach

Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015


BACKGROUND AND PURPOSE: We investigated whether hyperintensities with a diameter of at least 3, 3.5, and 4 cm and visible on at least 3 slices on diffusion-weighted imaging enables patient selection with an infarct volume of ≥15 mL. METHODS: Consecutive acute stroke patients were screened for the AXIS2 trial and examined according to a standardized magnetic resonance imaging protocol in 65 sites. Diffusion-weighted lesion diameters were measured and compared with volumetric assessments. RESULTS: Out of 238 patients, 86.2% (N=206) had infarct diameter of at least 3 cm. Volumetric assessments showed infarct volume of ≥15 mL in 157 patients. A cut-off value of 3 cm led to 96.8% sensitivity and ..

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