Familial occurrence and heritable connective tissue disorders in cervical artery dissection
Stephanie Debette, Barbara Goeggel Simonetti, Sabrina Schilling, Juan Jose Martin, Manja Kloss, Hakan Sarikaya, Ingrid Hausser, Stefan Engelter, Tiina M Metso, Alessandro Pezzini, Vincent Thijs, Emmanuel Touze, Stefano Paolucci, Paolo Costa, Maria Sessa, Yves Samson, Yannick Bejot, Ayse Altintas, Antti J Metso, Dominique Herve Show all
NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
OBJECTIVE: In a large series of patients with cervical artery dissection (CeAD), a major cause of ischemic stroke in young and middle-aged adults, we aimed to examine frequencies and correlates of family history of CeAD and of inherited connective tissue disorders. METHODS: We combined data from 2 large international multicenter cohorts of consecutive patients with CeAD in 23 neurologic departments participating in the CADISP-plus consortium, following a standardized protocol. Frequency of reported family history of CeAD and of inherited connective tissue disorders was assessed. Putative risk factors, baseline features, and 3-month outcome were compared between groups. RESULTS: Among 1,934 c..View full abstract
Awarded by Adrinord
Contrat de Projet Etat-Region; Projet Hospitalier de Recherche Clinique Regional; Fondation de France; Adrinord-EA2691; Institut Pasteur de Lille; INSERM U744; Emil Aaltonen, Paavo Ilmari Ahvenainen, Paivikki and Sakari Sohlberg, Aarne Koskelo, Maire Taponen, Aarne and Aili Turunen, Biomedicum Helsinki Foundation, Finnish Brain Foundation, Lilly, Alfred Kordelin, Orion-Farmos and Maud Kuistila Foundations; Finnish Medical Foundation; Helsinki University Central Hospital Research Fund; Academy of Finland; Helsinki University Medical Foundation; Basel Stroke-Funds; Kathe-Zingg-Schwichtenberg Fonds (Swiss Academy of Medical Sciences); Swiss Heart Foundation; Swiss National Science Foundation. Stephanie Debette is supported by a Chair of Excellence grant from the French National Research Agency (Agence Nationale de la Recherche) and from the Leducq Foundation. Vincent Thijs is supported by a Clinical Investigatorship from FWO Flanders.