Journal article
Familial occurrence and heritable connective tissue disorders in cervical artery dissection
Stephanie Debette, Barbara Goeggel Simonetti, Sabrina Schilling, Juan Jose Martin, Manja Kloss, Hakan Sarikaya, Ingrid Hausser, Stefan Engelter, Tiina M Metso, Alessandro Pezzini, Vincent Thijs, Emmanuel Touze, Stefano Paolucci, Paolo Costa, Maria Sessa, Yves Samson, Yannick Bejot, Ayse Altintas, Antti J Metso, Dominique Herve Show all
NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
Abstract
OBJECTIVE: In a large series of patients with cervical artery dissection (CeAD), a major cause of ischemic stroke in young and middle-aged adults, we aimed to examine frequencies and correlates of family history of CeAD and of inherited connective tissue disorders. METHODS: We combined data from 2 large international multicenter cohorts of consecutive patients with CeAD in 23 neurologic departments participating in the CADISP-plus consortium, following a standardized protocol. Frequency of reported family history of CeAD and of inherited connective tissue disorders was assessed. Putative risk factors, baseline features, and 3-month outcome were compared between groups. RESULTS: Among 1,934 c..
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Funding Acknowledgements
Contrat de Projet Etat-Region; Projet Hospitalier de Recherche Clinique Regional; Fondation de France; Adrinord-EA2691; Institut Pasteur de Lille; INSERM U744; Emil Aaltonen, Paavo Ilmari Ahvenainen, Paivikki and Sakari Sohlberg, Aarne Koskelo, Maire Taponen, Aarne and Aili Turunen, Biomedicum Helsinki Foundation, Finnish Brain Foundation, Lilly, Alfred Kordelin, Orion-Farmos and Maud Kuistila Foundations; Finnish Medical Foundation; Helsinki University Central Hospital Research Fund; Academy of Finland; Helsinki University Medical Foundation; Basel Stroke-Funds; Kathe-Zingg-Schwichtenberg Fonds (Swiss Academy of Medical Sciences); Swiss Heart Foundation; Swiss National Science Foundation. Stephanie Debette is supported by a Chair of Excellence grant from the French National Research Agency (Agence Nationale de la Recherche) and from the Leducq Foundation. Vincent Thijs is supported by a Clinical Investigatorship from FWO Flanders.