Stroke in first-degree relatives of patients with cervical artery dissection
M Kloss, C Grond-Ginsbach, A Pezzini, TM Metso, AJ Metso, S Debette, D Leys, J Dallongeville, V Caso, V Thijs, A Bersano, E Touze, LH Bonati, T Tatlisumak, M-L Arnold, PA Lyrer, ST Engelter
European Journal of Neurology | WILEY-BLACKWELL | Published : 2014
BACKGROUND AND PURPOSE: Patients with ischaemic stroke (IS) caused by a spontaneous cervical artery dissection (CeAD) worry about an increased risk for stroke in their families. The occurrence of stroke in relatives of patients with CeAD and in those with ischaemic stroke attributable to other (non-CeAD) causes were compared. METHODS: The frequency of stroke in first-degree relatives (family history of stroke, FHS) was studied in IS patients (CeAD patients and age- and sex-matched non-CeAD patients) from the Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) database. FHS ≤ 50 and FHS > 50 were defined as having relatives who suffered stroke at the age of ≤50 or >50 years. FHS ..View full abstract
Awarded by Adrinord
Awarded by Swiss National Science Foundation
The authors thank the patients who participated in this study and all staff and participants at all CADISP centers for their contributions. The CADISP study has received funding from the Contrat de Projet Etat-Region 2007, Centre National de Genotypage, Emil Aaltonen Foundation, Paavo Ilmari Ahvenainen Foundation, Helsinki University Central Hospital Research Fund, Academy of Finland, Helsinki University Medical Foundation, Paivikki and Sakari Sohlberg Foundation, Aarne Koskelo Foundation, Maire Taponen Foundation, Aarne and Aili Turunen Foundation, Lilly Foundation, Alfred Kordelin Foundation, Finnish Medical Foundation, Orion Farmos Research Foundation, Maud Kuistila Foundation, the Finnish Brain Foundation, Biomedicum Helsinki Foundation, Projet Hospitalier de Recherche Clinique Regional, Fondation de France, Genopole de Lille, Adrinord, EA2691, Institut Pasteur de Lille, INSERM U744, Basel Stroke-Funds, Kathe-Zingg-Schwichtenberg-Fonds of the Swiss Academy of Medical Sciences, the Swiss National Science Foundation (33CM30-124119; 33CM30-140340/1) and Swiss Heart Foundation.